DPYSL3

DPYSL3, also known as Dihydropyrimidinase-Related Protein 3, is a protein encoded by the DPYSL3 gene in humans. It is a member of the collapsin response mediator protein (CRMP) family, also known as dihydropyrimidinase-related proteins (DRPs). These proteins are involved in neuronal development, axon guidance, growth cone collapse, and neuronal polarity.

Specifically, DPYSL3 plays a role in signal transduction pathways that regulate cytoskeletal dynamics, influencing the shape and movement of neurons. It interacts with other proteins involved in these processes, contributing to the overall orchestration of neuronal growth and differentiation.

DPYSL3 is expressed in various tissues, with particularly high levels found in the developing and adult nervous system. Its expression patterns suggest a continuing role throughout the lifespan of an organism, not just during development.

The protein contains several phosphorylation sites, which regulate its activity and interactions with other proteins. These phosphorylation events can be influenced by various signaling pathways, further modulating the function of DPYSL3 in different cellular contexts.

Dysregulation of DPYSL3 has been implicated in various neurological disorders. Research suggests its potential involvement in conditions such as schizophrenia, autism spectrum disorder, and Alzheimer's disease, although the exact mechanisms and contributions are still being investigated. Studies focusing on the role of DPYSL3 in these diseases are ongoing.