SLC46A3

SLC46A3, also known as solute carrier family 46 member 3, is a gene that encodes a transmembrane protein. This protein belongs to the SLC46 family of transporters, which are involved in the transport of various solutes across cellular membranes.

While the precise substrate specificity and physiological role of SLC46A3 are not completely understood, research suggests its involvement in folate transport, particularly in specific tissues. Folate is a crucial B vitamin involved in various metabolic processes, including DNA synthesis and cell growth. Disruption or dysfunction of folate transport can lead to developmental abnormalities and other health issues.

SLC46A3 is expressed in various tissues throughout the body, with relatively high expression levels observed in the brain, placenta, and small intestine. This expression pattern hints at its potential roles in brain development, nutrient transport during pregnancy, and intestinal absorption of nutrients.

Further research is ongoing to fully elucidate the function of SLC46A3 and its potential implications in human health and disease. Understanding its role in folate transport and other cellular processes may lead to the development of novel therapeutic strategies for conditions related to folate deficiency or metabolic disorders.