NamiRNAs

NamiRNAs (nanomaterial-induced microRNAs) are microRNAs (miRNAs) whose expression levels are altered in cells and organisms following exposure to nanomaterials. These alterations in miRNA expression can contribute to the nanomaterial's biological effects, including toxicity, inflammation, and changes in cellular function. The specific NamiRNAs affected depend on factors such as the type, size, shape, surface chemistry, and concentration of the nanomaterial, as well as the cell type or organism exposed.

NamiRNAs are identified through techniques like miRNA sequencing (miRNA-seq) and quantitative PCR (qPCR), where miRNA expression profiles of cells exposed to nanomaterials are compared to those of control cells. Changes in miRNA expression patterns can then be correlated with observed biological responses.

Understanding NamiRNAs is important for assessing the safety and potential applications of nanomaterials. By identifying the miRNAs that are dysregulated by nanomaterials, researchers can gain insights into the underlying mechanisms of nanomaterial toxicity and develop strategies to mitigate adverse effects. Conversely, the ability to control miRNA expression through nanomaterial delivery holds potential for therapeutic applications.

Further research is ongoing to elucidate the complex interactions between nanomaterials and miRNA regulation, paving the way for safer and more effective use of nanotechnology.