MRPS35

MRPS35, or Mitochondrial Ribosomal Protein S35, is a protein found in eukaryotic organisms, including humans. It is a component of the mitochondrial ribosome, specifically the small subunit (28S mitoribosome). Mitochondrial ribosomes are responsible for the synthesis of proteins encoded by mitochondrial DNA (mtDNA) within the mitochondria, the cell's powerhouses.

MRPS35 plays a crucial role in the structural integrity and functional activity of the mitochondrial ribosome. While the precise function of MRPS35 remains under investigation, it is believed to be involved in the assembly, stability, and translational fidelity of the mitoribosome. Deficiencies or mutations in MRPS35 can disrupt mitochondrial protein synthesis, potentially leading to various mitochondrial disorders.

Mitochondrial disorders are a heterogeneous group of genetic diseases that arise from dysfunction of the mitochondrial respiratory chain. These disorders can affect multiple organ systems, particularly those with high energy demands, such as the brain, heart, and muscles. Research into MRPS35 and other mitochondrial ribosomal proteins is vital for understanding the pathogenesis of mitochondrial diseases and developing potential therapeutic interventions. The gene encoding human MRPS35 is located on a specific chromosome, and its expression is regulated by cellular factors. Further studies are required to fully elucidate the complex interactions and precise roles of MRPS35 in mitochondrial protein synthesis and cellular function.