MOBKL2A

MOBKL2A is a human gene that encodes for a protein belonging to the Mps One Binder kinase activator-like (MOBKL) family. Also known as Mob1B, this protein is involved in cell cycle regulation, specifically during mitosis.

Function:

The MOBKL2A protein is a regulatory subunit of the protein kinase complex known as STRIPAK (Striatin-interacting phosphatase and kinase). STRIPAK complexes are implicated in various cellular processes including cell signaling, cell migration, and cell polarity. MOBKL2A specifically binds to and activates several kinases, influencing downstream signaling pathways. Its role in mitosis involves regulating the accurate segregation of chromosomes during cell division, ensuring each daughter cell receives the correct genetic material. Dysregulation of MOBKL2A has been implicated in certain cancers, due to its influence on cell proliferation and genomic stability.

Structure:

The MOBKL2A protein contains a conserved MOB domain, characteristic of the MOBKL family. This domain is essential for protein-protein interactions, particularly with kinases and other regulatory proteins within the STRIPAK complex. The specific tertiary structure of MOBKL2A allows it to bind to its target kinases and modulate their activity.

Clinical Significance:

Research suggests that altered expression or mutations in the MOBKL2A gene may contribute to the development or progression of certain cancers. Specifically, studies have shown that abnormal MOBKL2A levels can disrupt mitotic checkpoints, leading to genomic instability and uncontrolled cell growth. Further research is being conducted to fully elucidate the precise role of MOBKL2A in tumorigenesis and to explore its potential as a therapeutic target.

See Also:

• STRIPAK complex
• Cell cycle
• Mitosis
• Protein kinase
• MOBKL family