RETNLB

RETNLB (Resistin-Like Beta) is a protein belonging to the resistin-like molecule (RELM) family, also known as the found in inflammatory zone (FIZZ) family. These proteins are secreted cysteine-rich proteins primarily expressed in adipose tissue and/or epithelial cells, depending on the specific RELM family member and species.

RETNLB, like other RELM proteins, is thought to play a role in inflammation, wound healing, and metabolic regulation, although its precise functions remain under investigation. It is notably different from resistin (RETN), another member of the same superfamily, in terms of its expression patterns and biological activities. While resistin is predominantly expressed by adipocytes in rodents and macrophages in humans, RETNLB expression is often associated with epithelial cells, particularly in the gastrointestinal tract.

In humans, RETNLB is encoded by the RETNLB gene. Research suggests a potential role for RETNLB in intestinal inflammation and immune responses, potentially influencing conditions like inflammatory bowel disease (IBD). Studies have also explored the role of RETNLB in the context of parasitic infections.

Further research is needed to fully elucidate the precise physiological and pathological roles of RETNLB and its contribution to human health and disease.