METTL16

METTL16, or Methyltransferase Like 16, is a protein-coding gene in humans and other organisms. It encodes an RNA methyltransferase that catalyzes the N6-methyladenosine (m6A) modification of specific RNA sequences.

METTL16 plays a crucial role in various cellular processes, most notably in regulating the processing and expression of the maternally expressed gene 3 (MEG3) non-coding RNA. MEG3 is an imprinted gene involved in tumor suppression, and METTL16-mediated m6A modification is essential for its correct splicing and stability.

The protein is a member of the methyltransferase superfamily and contains a characteristic methyltransferase domain. It recognizes a specific stem-loop structure within its RNA targets, allowing for precise methylation at the adenosine residue.

Dysregulation of METTL16 expression or activity has been implicated in various diseases, including cancer. Alterations in its function can disrupt MEG3 processing and expression, potentially contributing to tumorigenesis. Research is ongoing to further elucidate the precise roles of METTL16 in different tissues and disease states, and to explore its potential as a therapeutic target.