Biscaline

Biscaline is a synthetic phenethylamine derivative and structural analog of mescaline. It contains two methoxy groups and an ethyl group on the benzene ring, in positions corresponding to 2,5-dimethoxy-4-ethylamphetamine (DOET), but lacks the amphetamine side-chain alpha-methyl. Biscaline compounds (often referred to collectively as biscalines) represent a family of psychedelic substances with varying potencies and effects depending on the specific substitution pattern. They are typically synthesized from substituted benzaldehydes via multi-step organic chemistry processes.

The biscaline family includes compounds like biscaline, biscaline-HBr, and other analogs featuring modifications at the 4-position of the benzene ring (e.g., 4-halogenated or 4-alkyl biscalines). Their pharmacological effects are thought to primarily stem from agonist activity at serotonin 5-HT2A receptors in the brain. The effects can vary considerably, but often include alterations in perception, mood, and cognition, similar to other psychedelic drugs.

The legality of biscaline compounds varies by jurisdiction. Many are unscheduled in some regions, while others may fall under analogue laws due to their structural similarity to controlled substances like mescaline. They are primarily encountered as research chemicals and are not generally available through regulated pharmaceutical channels. Use carries inherent risks, including unpredictable psychological effects and potential for adverse interactions with other substances. Information about the synthesis, effects, and legal status of specific biscaline derivatives should be carefully researched before any experimentation.