(+)-CPCA
(+)-CPCA refers to (+)-Cyclopentyladenosine, a selective adenosine A1 receptor agonist. Adenosine receptors are G protein-coupled receptors that modulate a variety of physiological processes, including neurotransmission, cardiac function, and immune response. There are four known subtypes: A1, A2A, A2B, and A3.
(+)-CPCA is a potent and selective agonist for the A1 receptor subtype, meaning it preferentially binds to and activates this particular adenosine receptor. Activation of the A1 receptor often results in inhibitory effects, such as reducing neuronal excitability and slowing heart rate.
Due to its selectivity, (+)-CPCA is a valuable tool in pharmacological research for studying the specific role of the A1 adenosine receptor in various biological systems. It has been used in studies investigating the A1 receptor's involvement in conditions such as epilepsy, pain, and neuroprotection.
The "+" prefix indicates that the molecule is the dextrorotatory enantiomer, meaning it rotates plane-polarized light in a clockwise direction. The stereochemistry of the molecule is important for its binding affinity and selectivity to the A1 receptor. The opposite enantiomer, (-)-CPCA, typically exhibits weaker activity at the A1 receptor.