TMSB10

TMSB10, also known as Thymosin Beta 10, is a highly conserved protein belonging to the thymosin family of peptides. These peptides are characterized by their small size and acidic nature. Thymosin Beta 10 is encoded by the TMSB10 gene.

Function:

TMSB10 is believed to play a role in various cellular processes, including cell proliferation, differentiation, migration, and apoptosis. Its expression levels are often altered in cancer cells, suggesting a potential involvement in tumor development and progression. Research indicates it may interact with the actin cytoskeleton, influencing cell motility and morphology.

Structure:

Thymosin Beta 10 is a short polypeptide chain. Its amino acid sequence is highly conserved across different species, indicating its evolutionary importance.

Expression:

TMSB10 is widely expressed in different tissues and cell types. However, its expression patterns can vary depending on the developmental stage, physiological conditions, and disease state.

Clinical Significance:

Due to its involvement in cell growth and survival, TMSB10 has been implicated in several diseases, particularly cancer. It has been reported to be upregulated in some cancers and downregulated in others, suggesting that its role can be context-dependent. Further research is ongoing to fully understand the clinical significance of TMSB10 and its potential as a therapeutic target or biomarker.

Related Proteins:

The thymosin family includes other members like Thymosin Beta 4 (TMSB4X), which shares structural similarity with TMSB10 and also interacts with actin.