TMEM26

TMEM26 is a gene in humans that encodes a transmembrane protein. The official full name of the gene is Transmembrane Protein 26. This protein's precise function is not fully elucidated, but it is implicated in various cellular processes, particularly those related to adipocyte differentiation and energy metabolism.

Function

Research suggests that TMEM26 plays a role in the regulation of adipogenesis, the formation of new fat cells. It has been shown to be involved in the signaling pathways that control the differentiation of preadipocytes into mature adipocytes. Studies have also indicated a potential link between TMEM26 expression and energy expenditure, suggesting a possible role in regulating metabolism.

Expression

TMEM26 is expressed in a variety of tissues, including adipose tissue (both brown and white), and skeletal muscle. Its expression levels can vary depending on factors such as diet, exercise, and age.

Clinical Significance

Given its involvement in adipocyte differentiation and metabolism, TMEM26 has garnered interest as a potential target for therapies aimed at treating obesity and related metabolic disorders. Further research is needed to fully understand its role in these diseases and to explore its therapeutic potential. Single nucleotide polymorphisms (SNPs) in or near the TMEM26 gene have been associated with variations in body mass index (BMI) and other metabolic traits in some genome-wide association studies.