PPP1CB

PPP1CB, also known as Protein Phosphatase 1 Catalytic Subunit Beta, is a gene in humans that encodes a serine/threonine protein phosphatase catalytic subunit. It is a member of the protein phosphatase 1 (PP1) family, which plays a critical role in regulating a wide range of cellular processes, including cell division, muscle contraction, glycogen metabolism, RNA splicing, and neuronal signaling.

The PP1 family is highly conserved across eukaryotes, highlighting its importance in fundamental cellular functions. These phosphatases remove phosphate groups from proteins, reversing the action of protein kinases and thereby controlling protein activity and cellular signaling pathways. PP1 catalytic subunits, like PPP1CB, associate with regulatory subunits to form holoenzymes with specific substrate specificities and subcellular localizations.

PPP1CB is expressed in various tissues, including the brain, heart, and skeletal muscle, where it participates in numerous physiological processes. Its activity is tightly regulated by various factors, including phosphorylation, inhibitor proteins, and the association with regulatory subunits.

Dysregulation of PPP1CB has been implicated in several diseases, including neurological disorders, cardiovascular diseases, and cancer. Research into the function and regulation of PPP1CB is ongoing to better understand its role in health and disease, with the goal of developing potential therapeutic interventions.