Ole Kiehn

Ole Kiehn is a Danish neuroscientist known for his research on the neural circuits underlying locomotion, particularly spinal cord circuits involved in generating rhythmic movements like walking. His work has significantly contributed to understanding how the spinal cord can produce coordinated movement patterns even in the absence of input from the brain.

Kiehn's research employs a variety of techniques including electrophysiology, optogenetics, and molecular biology to identify and characterize the specific neurons and circuits responsible for different aspects of locomotion. He has made key discoveries regarding the roles of specific interneuron populations in the spinal cord, such as V0, V1, and V2a interneurons, in coordinating left-right and flexor-extensor movements.

His lab, located at the Department of Neuroscience at the Karolinska Institute in Stockholm, Sweden, continues to investigate the fundamental mechanisms of motor control and how these mechanisms are affected in neurological disorders such as spinal cord injury and amyotrophic lateral sclerosis (ALS). The long-term goal of his research is to develop therapeutic strategies to restore motor function in individuals with these conditions.

Kiehn has received numerous awards and honors for his contributions to neuroscience, reflecting the significant impact of his work on the field. He is considered a leading figure in the study of motor control and spinal cord circuits.