John Scott (medical researcher)

John Scott is a biochemist and molecular pharmacologist primarily known for his work on A-kinase anchoring proteins (AKAPs) and their role in cellular signaling. He is a Professor in the Department of Pharmacology at the University of Washington in Seattle.

Scott's research has focused on understanding how AKAPs organize signaling pathways within cells by targeting protein kinases and phosphatases to specific locations. His laboratory has identified and characterized numerous AKAPs, elucidating their structural features and interactions with other signaling molecules. This work has contributed significantly to the understanding of compartmentalized signaling and its importance in regulating cellular function.

Key contributions include the discovery and characterization of the first AKAP, AKAP79, and subsequent identification of numerous other AKAP family members. His research has explored the role of AKAPs in various physiological processes, including cardiac function, neuronal signaling, and immune cell activation. Studies have investigated the dysregulation of AKAP signaling in disease states, offering potential therapeutic targets.

Scott's research has been published extensively in leading scientific journals and has been recognized with numerous awards. He continues to be a prominent figure in the field of signal transduction research.