HSD17B8

HSD17B8 (Hydroxysteroid 17-Beta Dehydrogenase 8) is a gene that encodes for a protein belonging to the short-chain dehydrogenases/reductases (SDR) superfamily. The protein is also known as SDR16C1 (Short-Chain Dehydrogenase/Reductase Family 16C, Member 1). HSD17B8 is involved in the metabolism of steroids, specifically functioning as a reductase that catalyzes the conversion of certain steroids to their respective 17β-hydroxy forms. This activity plays a role in regulating the levels and activity of steroid hormones.

The enzyme encoded by HSD17B8 demonstrates activity towards a range of substrates including androgens, estrogens, and bile acids. It is particularly important in the synthesis and regulation of dihydrotestosterone (DHT) and estradiol.

The HSD17B8 gene is expressed in various tissues, including the liver, prostate, and brain, which reflects the diverse roles steroid hormones play in the body. Disruption or dysregulation of HSD17B8 function has been implicated in various conditions, including hormone-dependent cancers and metabolic disorders. Further research is ongoing to fully elucidate the specific roles of HSD17B8 in different physiological and pathological contexts. The protein's involvement in steroid metabolism makes it a potential therapeutic target for various endocrine-related diseases.