GPR141

GPR141 is a human gene that encodes for a G protein-coupled receptor (GPCR) of unknown function. It is also known as orphan receptor GPR141.

Gene Information:

The GPR141 gene is located on chromosome 11q23.3. Its exact genomic organization and flanking genes can be found in publicly available databases like NCBI Gene.

Protein Information:

The protein encoded by GPR141 is a transmembrane receptor, characterized by the seven transmembrane domains typical of GPCRs. The predicted amino acid sequence suggests structural features common to GPCRs, including extracellular N-terminus and intracellular C-terminus, along with conserved cysteine residues that form disulfide bonds crucial for protein folding and stability. The predicted molecular weight is in the range typically observed for GPCRs.

Function:

As an orphan receptor, the endogenous ligand for GPR141 has not yet been identified. Therefore, the physiological role and signaling pathways mediated by GPR141 are currently unknown. Research efforts are ongoing to identify its ligand and elucidate its potential functions in various biological processes.

Expression:

Expression studies, often involving techniques like RT-PCR and immunohistochemistry, have reported varying levels of GPR141 mRNA and protein in different human tissues. Tissue distribution data provides clues for potential roles of the receptor in those specific tissues.

Clinical Significance:

Due to its unknown function, the direct clinical significance of GPR141 is not well-established. However, as a GPCR, it is a potential drug target. Future research may uncover its involvement in various diseases, making it a relevant therapeutic target. Understanding its function and ligand interaction could lead to the development of novel drugs for relevant diseases.