ENTPD2

ENTPD2, also known as ectonucleoside triphosphate diphosphohydrolase 2, is a human gene encoding an enzyme that belongs to the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) family. This family of enzymes is responsible for hydrolyzing extracellular nucleoside triphosphates and diphosphates, playing a crucial role in regulating purinergic signaling.

The ENTPD2 protein, also known as CD39L1 (CD39-like 1), is a type II transmembrane glycoprotein. It is predominantly expressed in the brain, liver, and placenta, though it can also be found in other tissues. ENTPD2's primary function is the sequential hydrolysis of ATP to ADP, and then ADP to AMP. This activity modulates the levels of extracellular ATP and ADP, which are important signaling molecules involved in various physiological processes, including platelet aggregation, inflammation, and neurotransmission.

Dysregulation of ENTPD2 activity has been implicated in several pathological conditions, including cardiovascular diseases, cancer, and neurodegenerative disorders. Research suggests that ENTPD2 may serve as a potential therapeutic target for these conditions.

Further research is ongoing to fully elucidate the specific roles of ENTPD2 in different tissues and its contribution to overall health and disease.