Cyclic alcohol dehydrogenase (quinone)

Cyclic alcohol dehydrogenase (quinone) is an enzyme classified under the oxidoreductase family (EC 1.1.5.8). This enzyme catalyzes the oxidation of cyclic alcohols, utilizing a quinone as an electron acceptor. Specifically, it catalyzes the following reaction:

a cyclic alcohol + quinone <=> a cyclic ketone + quinol

The enzyme plays a role in the metabolism of cyclic compounds in certain microorganisms. It is typically found associated with the cell membrane, facilitating electron transfer to the quinone pool. The quinone acts as a mobile electron carrier, transferring electrons from the cyclic alcohol dehydrogenase to other respiratory chain components, ultimately contributing to ATP generation through oxidative phosphorylation.

The substrate specificity of cyclic alcohol dehydrogenase (quinone) can vary depending on the organism from which it is derived. Some enzymes exhibit a preference for specific ring sizes or substituents on the cyclic alcohol. The quinone acceptor can also vary, with some enzymes utilizing ubiquinone, menaquinone, or other quinone derivatives.

The systematic name for this enzyme is cyclic-alcohol:quinone oxidoreductase. Other names that may be used include cyclohexanol dehydrogenase (quinone) and cyclic alcohol dehydrogenase (acceptor).