CNKSR3

CNKSR3 is a human gene that encodes for a member of the connector enhancer of kinase suppressor of Ras (CNK) family of scaffold proteins. These proteins are characterized by multiple protein-protein interaction domains, including a sterile alpha motif (SAM) domain, a pleckstrin homology (PH) domain, and several proline-rich regions.

CNKSR3 proteins function as molecular scaffolds, bringing together components of signaling pathways, particularly those related to the Ras/MAPK (mitogen-activated protein kinase) pathway. By facilitating the interaction of pathway components, CNKSR3 can modulate the activity and specificity of signaling.

While the precise roles of CNKSR3 are still being investigated, it is believed to be involved in a variety of cellular processes, including cell growth, differentiation, and survival. Research suggests CNKSR3 may play a role in neuronal development and function. Disruption or dysregulation of CNKSR3 expression or function may be implicated in certain developmental disorders or diseases.

The gene encoding CNKSR3 is located on a specific chromosome, and its expression can be regulated by various factors, including transcription factors and signaling molecules. Further research is needed to fully elucidate the precise mechanisms by which CNKSR3 functions and its role in various physiological and pathological processes.