SCH-58261

SCH-58261 is a chemical compound that acts as a selective adenosine A2A receptor antagonist. Adenosine A2A receptors are G protein-coupled receptors that play a role in a variety of physiological processes, including vasodilation, neuromodulation, and immune function.

As an antagonist, SCH-58261 binds to the A2A receptor but does not activate it. This blocks the binding of adenosine, the receptor's natural ligand, and prevents the downstream signaling cascade that adenosine would normally initiate.

SCH-58261 has been utilized extensively in research to study the role of A2A receptors in various biological systems. Specific areas of investigation have included:

• Parkinson's disease: Studies have explored the potential of A2A receptor antagonists, including SCH-58261, for the treatment of Parkinson's disease, based on the receptor's involvement in basal ganglia function.
• Inflammation: Research has examined the effects of A2A receptor blockade by SCH-58261 on inflammatory responses.
• Neuroprotection: The potential of A2A receptor antagonism to protect neurons from damage has been investigated using SCH-58261.

SCH-58261 is primarily used as a research tool and is not currently approved for therapeutic use in humans. It is generally available from chemical suppliers for laboratory research purposes. Its effects in vivo can vary depending on the dosage and route of administration. It is critical to consult relevant scientific literature for detailed information on the compound's properties and potential applications.