CLIP1

CLIP1 is a human gene encoding for CapZ-interacting protein 1. CapZ-interacting proteins, including CLIP1, are known to play a role in regulating actin filament dynamics at the barbed ends. Actin filaments are crucial components of the cytoskeleton, responsible for cell shape, motility, and division.

The CLIP1 protein interacts directly with CapZ (capping protein), a heterodimeric protein that caps the barbed ends of actin filaments, preventing the addition or loss of actin monomers. By modulating CapZ activity, CLIP1 influences the polymerization and depolymerization of actin filaments, thereby contributing to the control of actin-based structures.

The precise function of CLIP1 is not yet fully understood, but research suggests its involvement in various cellular processes, including cell migration, adhesion, and morphogenesis. Studies have shown that CLIP1 expression and localization are tissue-specific, suggesting diverse roles depending on the cellular context. Dysregulation of CLIP1 has been implicated in certain diseases, warranting further investigation into its potential therapeutic relevance. Alternative splicing of the CLIP1 gene can produce multiple transcript variants, further adding to the complexity of its function.