CIAPIN1

CIAPIN1 (Cytokine-induced apoptosis inhibitor 1), also known as PPP1R15B (Protein Phosphatase 1 Regulatory Subunit 15B), is a protein encoded by the CIAPIN1 gene in humans. This protein plays a role in cell survival and apoptosis.

CIAPIN1 is a member of the CIAPIN family, characterized by a conserved CIAPIN domain. It is involved in the regulation of cell death pathways, specifically acting as an inhibitor of apoptosis induced by certain cytokines. The exact mechanism of action is still under investigation, but it is thought to involve interactions with other proteins involved in apoptosis signaling cascades.

Research suggests that CIAPIN1 expression is altered in various cancers, and it may play a role in tumor development and progression. Its expression levels can vary depending on the cancer type, sometimes promoting cell survival and resistance to chemotherapy, while in other contexts, it might act as a tumor suppressor.

Further research is ongoing to fully elucidate the role of CIAPIN1 in different cellular processes and its potential as a therapeutic target.