CDC2L2

CDC2L2 (Cell Division Cycle 2-Like 2), also known as CDK11 (Cyclin-Dependent Kinase 11), is a serine/threonine kinase enzyme that plays a role in cell cycle regulation, mRNA processing, and apoptosis. It is a member of the cyclin-dependent kinase (CDK) family, a group of protein kinases essential for controlling the progression of the cell cycle.

CDC2L2 exists in two major isoforms, CDK11p58 and CDK11p46, generated through alternative splicing and proteolytic cleavage. These isoforms have distinct but overlapping functions. CDK11p58 is involved in mitotic regulation and chromosome segregation, while CDK11p46 is primarily associated with pre-mRNA splicing and is produced during apoptosis.

The activity of CDC2L2 is regulated by cyclins, specifically cyclin L. Upon binding to cyclin L, CDC2L2 is activated and can phosphorylate its target proteins. CDK11 also interacts with other proteins involved in RNA processing, such as SR proteins, further highlighting its role in splicing.

Dysregulation of CDC2L2 has been implicated in various diseases, including cancer. Its involvement in cell cycle control makes it a potential target for cancer therapy. Specifically, its role in mRNA processing may contribute to aberrant gene expression patterns observed in tumor cells. Research is ongoing to fully elucidate the mechanisms by which CDC2L2 contributes to oncogenesis and to develop targeted therapies that modulate its activity.