BOK (gene)

BOK, also known as BCL2-related ovarian killer protein, is a pro-apoptotic member of the BCL-2 protein family. These proteins regulate programmed cell death (apoptosis) by controlling mitochondrial membrane permeability. BOK is characterized by the presence of BH1, BH2, and BH3 domains, which are crucial for protein-protein interactions within the BCL-2 family.

BOK is widely expressed in mammalian tissues, including the ovaries, and plays a role in regulating cell death in these tissues. Unlike some other BCL-2 family members, BOK lacks a transmembrane domain, which may influence its mechanism of action.

The precise function of BOK is still under investigation, but studies suggest its involvement in developmental processes and tumor suppression. Specifically, BOK appears to be essential for normal female reproductive tract development and has been implicated in the regulation of oocyte apoptosis. Dysregulation of BOK expression or function has been observed in some cancers, indicating a potential role in tumorigenesis.

Further research is necessary to fully elucidate the mechanisms by which BOK contributes to apoptosis and its overall impact on cell survival and disease.