AP-7 (drug)
AP-7, also known as 2-amino-7-phosphonoheptanoic acid, is a selective NMDA receptor antagonist. It is a structural analog of glutamic acid, a primary excitatory neurotransmitter in the central nervous system. AP-7 competitively inhibits the binding of glutamate and related agonists to the NMDA receptor complex.
AP-7 is primarily used in research settings to study the role of NMDA receptors in various neurological and physiological processes. These processes include synaptic plasticity, learning and memory, neuronal development, and excitotoxicity. Because of its ability to block NMDA receptor activation, it has been used to investigate the effects of NMDA receptor blockade on different brain functions and behaviors.
AP-7 is typically administered through intracerebral injection or infusion, limiting its practical use as a systemic drug. Its effects are generally localized to the region of administration. While possessing potential neuroprotective properties in experimental models of brain injury and stroke, its primary application remains within basic science research.
The compound exists as various stereoisomers, with the most commonly used form being the D-AP7 stereoisomer.
See Also:
- NMDA receptor
- Glutamate
- Excitotoxicity
- NMDA receptor antagonist