ALOX12

ALOX12 (Arachidonate 12-Lipoxygenase) is a gene that encodes for the 12-lipoxygenase enzyme. In humans, it is located on chromosome 17p13.1. The protein product, 12-lipoxygenase, is a non-heme iron containing dioxygenase that catalyzes the addition of molecular oxygen to polyunsaturated fatty acids, primarily arachidonic acid, resulting in the formation of hydroperoxy derivatives, such as 12(S)-hydroperoxyeicosatetraenoic acid (12(S)-HETE).

12-Lipoxygenase enzymes are involved in various biological processes, including inflammation, cell differentiation, and platelet aggregation. Different isoforms of 12-lipoxygenase exist in mammals.

The ALOX12 gene is expressed in a variety of tissues, including skin, platelets, and prostate. Dysregulation of ALOX12 expression and activity has been implicated in several diseases, including psoriasis, cancer, and cardiovascular disease. Research suggests it plays a role in lipid metabolism and signaling pathways involved in cellular growth and survival. Further research is ongoing to fully elucidate the precise roles and mechanisms of ALOX12 in various physiological and pathological conditions. Polymorphisms in the ALOX12 gene have also been studied in relation to disease susceptibility.