STOML2

STOML2, standing for "Stomatin-Like Protein 2," is a human gene that encodes a protein belonging to the stomatin family. These proteins are integral membrane proteins thought to play a role in mechanotransduction, cell adhesion, and ion channel regulation.

The STOML2 protein is characterized by a highly conserved N-terminal region known as the SPFH (stomatin, prohibitin, flotillin, and HflK/C) domain. This domain is involved in protein-protein interactions and membrane localization.

Functionally, STOML2 is implicated in various cellular processes. Studies suggest its involvement in the regulation of ion channels, particularly acid-sensing ion channels (ASICs). It is also believed to participate in the formation of membrane microdomains, influencing cell signaling and membrane trafficking.

STOML2 expression is observed in a variety of tissues, with notable levels in the brain and nervous system, suggesting a potential role in neuronal function. Research has explored the potential involvement of STOML2 in neurological disorders, although the specific mechanisms remain under investigation.

The gene encoding STOML2 is located on chromosome 12q13.12. Genetic variations within the STOML2 gene have been studied for potential associations with various phenotypes, but further research is needed to fully elucidate the functional consequences of these variations.