SNN (gene)

SNN refers to the gene encoding Stannin, a protein found in vertebrates.

Function: Stannin is a protein involved in the nervous system, specifically in neuronal survival and protection against neurotoxic insults. It has been shown to protect neurons from various types of cell death, including apoptosis and necrosis, induced by toxins such as tributyltin (TBT). While the exact mechanism of action is still being investigated, stannin is thought to interact with components of the apoptotic pathway and may also play a role in regulating cellular calcium levels.

Expression: Stannin is primarily expressed in the brain, particularly in neurons. Its expression levels can vary depending on the brain region and developmental stage. Lower levels of expression have also been found in other tissues.

Clinical Significance: Dysregulation of stannin expression or function has been implicated in neurodegenerative diseases and other neurological disorders. Studies have suggested a potential link between altered stannin levels and conditions such as Alzheimer's disease and Parkinson's disease. Further research is ongoing to fully elucidate the role of stannin in these and other neurological diseases.

Related Research: Research on stannin continues to focus on its neuroprotective mechanisms, its interaction with other cellular proteins, and its potential as a therapeutic target for neurological disorders. Studies also aim to understand the precise regulation of stannin gene expression in different cellular contexts.