SLITRK2

SLITRK2 is a gene in humans that encodes a transmembrane protein belonging to the SLITRK family. This family of proteins is characterized by leucine-rich repeats (LRRs) and a cytoplasmic domain that interacts with tyrosine kinases.

SLITRK2 is primarily expressed in the nervous system, with higher levels of expression observed in specific brain regions. While its precise function is still under investigation, SLITRK2 is thought to play a role in neuronal development, synapse formation, and neuronal differentiation. It is believed to influence neurite outgrowth and branching.

Genetic studies have implicated SLITRK2 in various neurological and psychiatric disorders, including Tourette's syndrome, obsessive-compulsive disorder (OCD), and epilepsy. Variations in the SLITRK2 gene have been associated with an increased susceptibility to these conditions, suggesting a potential role in their pathogenesis. Further research is required to fully elucidate the mechanisms by which SLITRK2 contributes to these disorders.

The SLITRK family members share structural similarities, but they exhibit distinct expression patterns and potentially diverse functions within the nervous system. SLITRK2, like other members of the family, may interact with other proteins to regulate neuronal signaling pathways. The identification of these interacting proteins is an ongoing area of research.