SLC27A6

SLC27A6 is a human gene that encodes a protein known as Fatty Acid Transport Protein 6 (FATP6). FATP6 belongs to the SLC27 family of membrane proteins, which facilitate the uptake of long-chain fatty acids (LCFAs) across the plasma membrane. These proteins play a crucial role in lipid metabolism and energy homeostasis.

Function:

The primary function of FATP6 is believed to be involved in the cellular uptake of long-chain fatty acids. However, compared to other FATP family members, less is known about its specific substrates and regulatory mechanisms. It is thought to contribute to overall fatty acid transport capacity in cells where it is expressed. Some studies suggest potential roles in lipid synthesis and/or storage. FATP6 may also have roles in cell signaling pathways mediated by fatty acids. Research continues to further elucidate its precise functions.

Structure:

FATP6, like other FATP family members, is an integral membrane protein predicted to have multiple transmembrane domains. The specific topology and structural details of FATP6 are still being investigated. The protein contains conserved motifs characteristic of the SLC27 family, including an AMP-binding domain, which suggests a potential role in fatty acid metabolism coupled to ATP hydrolysis or AMP regulation.

Tissue Distribution:

Expression of the SLC27A6 gene has been observed in various human tissues, including the brain, skin, and adipose tissue. The levels of expression can vary depending on the tissue type and physiological conditions. Further research is needed to fully map the expression profile of FATP6 under different conditions.

Clinical Significance:

While the exact clinical significance of SLC27A6 is still under investigation, variations in the gene or alterations in its expression levels may be associated with metabolic disorders and other health conditions. Some studies have explored potential links between SLC27A6 and skin diseases, lipid metabolism disorders, and neurological function. More research is needed to determine the specific role of FATP6 in these diseases and to explore its potential as a therapeutic target.

Related Genes:

The SLC27 family consists of several members, including SLC27A1 (FATP1), SLC27A2 (FATP2), SLC27A3 (FATP3), SLC27A4 (FATP4), SLC27A5 (FATP5), and SLC27A6 (FATP6). These proteins share structural similarities and are involved in fatty acid transport, but they exhibit distinct tissue distribution patterns and substrate preferences. Understanding the interactions and functional overlap between these family members is crucial for a comprehensive understanding of lipid metabolism.