SB-200646

SB-200646 is a chemical compound that functions as a potent and selective antagonist of the dopamine D4 receptor. It belongs to the class of benzamide derivatives. SB-200646 has been primarily used as a research tool in pharmacology and neuroscience to investigate the role of the D4 receptor in various physiological and behavioral processes.

Specifically, studies using SB-200646 have explored the D4 receptor's involvement in cognition, particularly attention and working memory, as well as its potential role in modulating dopamine-related behaviors such as locomotor activity and drug seeking.

It is important to note that SB-200646 is generally used for in vitro and in vivo research and is not approved for therapeutic use in humans. The compound is available from various chemical suppliers for scientific purposes. Its effectiveness and selectivity have made it a valuable tool for researchers aiming to understand the complex functions of the D4 dopamine receptor subtype within the central nervous system.