Losing My Religion (Grey's Anatomy)

"Losing My Religion" is the title of the 27th and final episode of the second season of the American medical drama Grey's Anatomy. It originally aired on May 15, 2006. The episode is widely considered one of the most iconic and pivotal episodes in the series' history, marked by significant character developments and high-stakes medical drama.

The episode centers on several storylines, the most prominent being Izzie Stevens' romantic involvement with her patient, Denny Duquette, who is awaiting a heart transplant. Complications arise when Denny's condition deteriorates, leading Izzie to make a drastic decision that could jeopardize her career. The ethical implications of Izzie's actions are a major focus.

Other storylines within "Losing My Religion" include: Meredith Grey struggling with her feelings for Derek Shepherd, whose ex-wife Addison Montgomery is also present at Seattle Grace Hospital; George O'Malley's growing romantic feelings for Meredith, which are ultimately rejected; and Cristina Yang dealing with the aftermath of her ectopic pregnancy.

The title "Losing My Religion" is a metaphorical reference to the characters grappling with profound moral and ethical dilemmas, challenging their beliefs and values. It also alludes to the R.E.M. song of the same name, which plays during a key scene in the episode, further emphasizing the emotional weight of the events unfolding. The episode concludes with a shocking death, leaving the audience with a significant cliffhanger and setting the stage for the subsequent season. It is renowned for its dramatic intensity and exploration of complex character relationships.