Khellin

Khellin is a naturally occurring furanochromone, a type of organic chemical compound. It is found in plants such as Ammi visnaga (bishop's weed), traditionally used for medicinal purposes in the Middle East and North Africa.

Historically, khellin was investigated for its potential as a coronary vasodilator and bronchodilator. It was considered as a possible treatment for angina pectoris and asthma due to its ability to relax smooth muscle. However, its use was limited by its relatively low potency and the occurrence of side effects.

While khellin itself is no longer widely used in mainstream medicine, it served as a lead compound in the development of other pharmaceutical drugs. Specifically, khellin's structure inspired the development of amiodarone, a more potent and widely used antiarrhythmic drug.

Chemically, khellin is a crystalline solid with a molecular formula of C₁₄H₁₂O₅. It is relatively insoluble in water but soluble in organic solvents. The compound is characterized by its furanochromone core structure. Research has also investigated its potential anti-inflammatory and anti-cancer properties, although further studies are required to confirm these effects and understand the underlying mechanisms.