JWH-368

JWH-368 is a synthetic cannabinoid that belongs to the naphthoylindole chemical class. It acts as an agonist of the CB1 and CB2 cannabinoid receptors.

Synthesized by John W. Huffman's group at Clemson University, JWH-368 is structurally related to other JWH-series compounds, featuring a naphthalene ring system attached to an indole core. The "368" designation refers to its order of synthesis within the Huffman research program.

JWH-368 has been used in scientific research to study the cannabinoid receptor system. It has also appeared as an ingredient in synthetic cannabis products, often marketed as "spice" or "K2," though its prevalence has varied. The use of JWH-368 in such products has raised public health concerns due to the potential for adverse effects. Its legal status varies by jurisdiction; it is often controlled under drug analogue laws.

Due to the ever-evolving nature of synthetic cannabinoid research and legislation, information regarding its availability, effects, and legal status should be regularly updated from reputable sources.