JWH-309

JWH-309 is a synthetic cannabinoid that belongs to the naphthoylindole family. It acts as an agonist of the CB1 and CB2 cannabinoid receptors, similar to tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. JWH-309 was originally synthesized by John W. Huffman's research group at Clemson University and named after him (JWH).

The compound's effects are comparable to those of cannabis, and it has been used as an ingredient in synthetic cannabis products (also known as "spice" or "K2"). However, the use of JWH-309 and similar synthetic cannabinoids is associated with a range of adverse health effects, which can be more severe than those associated with natural cannabis. These effects can include anxiety, paranoia, psychosis, tachycardia, nausea, vomiting, and in some cases, death.

Because of its potential for abuse and associated health risks, JWH-309 has been made illegal in many countries. Its legal status varies, but it is often controlled under drug analogue laws, which prohibit substances that are structurally and pharmacologically similar to already-banned drugs. The use, sale, and possession of JWH-309 are often subject to criminal penalties. Its presence in unregulated synthetic cannabis products poses a public health concern due to unpredictable dosages and potential toxicities.