Iodamide

Iodamide is an organic iodine compound used as a radiocontrast agent. It belongs to the class of ionic, monomeric contrast media, meaning it is a salt-based compound with a single benzene ring structure and high osmolality. Iodamide contains three iodine atoms per molecule, contributing to its radiopacity, i.e., its ability to block X-rays and create contrast in medical imaging.

Iodamide is administered intravenously or intra-arterially to enhance the visibility of blood vessels and internal organs during radiographic procedures, such as computed tomography (CT) scans and angiography. It is excreted primarily by the kidneys.

Like other iodinated contrast agents, iodamide carries a risk of adverse reactions, including mild reactions such as nausea, vomiting, and skin rash, and more severe reactions such as anaphylaxis and contrast-induced nephropathy (CIN). Patients with pre-existing kidney disease, allergies to iodine, or other underlying medical conditions may be at higher risk for complications. Appropriate hydration and monitoring of kidney function are important measures to mitigate these risks.

The use of iodamide, while effective for certain diagnostic imaging applications, has largely been supplanted by newer, non-ionic contrast agents with lower osmolality, which are generally considered to be safer and better tolerated by patients.