IFL (chemotherapy)

IFL is a chemotherapy regimen used in the treatment of certain cancers, most notably colorectal cancer. It is an acronym that stands for the combination of the following chemotherapy drugs:

• Irinotecan: A topoisomerase I inhibitor, which disrupts DNA replication and cell division.

• Fluorouracil (5-FU): An antimetabolite that interferes with DNA and RNA synthesis.

• Leucovorin (Folinic Acid): A folate analog that enhances the activity of 5-FU. It is sometimes referred to as "LV" instead of "Leucovorin."

The IFL regimen is typically administered intravenously, with specific dosages and schedules determined by the oncologist based on the individual patient's condition, stage of cancer, and overall health. Common side effects of IFL can include, but are not limited to, nausea, vomiting, diarrhea, mucositis (inflammation of the mucous membranes), fatigue, and myelosuppression (suppression of bone marrow function, leading to low blood cell counts).