GPR144

GPR144 is a human gene that encodes a protein belonging to the G protein-coupled receptor (GPCR) superfamily. GPCRs are a large family of transmembrane receptors that mediate cellular responses to a wide variety of extracellular signals, including hormones, neurotransmitters, and sensory stimuli. They are characterized by their seven transmembrane domains and their ability to activate intracellular signaling pathways through interactions with heterotrimeric G proteins.

The specific function of GPR144 is not fully understood. It is classified as an orphan receptor, meaning that its endogenous ligand (the molecule that normally binds to and activates the receptor) has not yet been identified. Research suggests that GPR144 may be involved in various biological processes, and its expression has been observed in several tissues, including immune cells and the central nervous system.

Further research is needed to elucidate the specific roles of GPR144 in cellular signaling, physiology, and disease. Its identification as a GPCR suggests its potential as a therapeutic target, pending the discovery of its ligand and the elucidation of its downstream signaling pathways. The lack of knowledge surrounding its function presents a significant challenge in drug development, however. Investigations are ongoing to identify its ligand and characterize its signaling mechanisms.