FAM60A

FAM60A is a human gene that encodes a protein of unknown function. It is also known by several aliases, including C2orf12, KIAA1567, and protein FAM60A.

Gene Information

The FAM60A gene is located on chromosome 2 in humans, specifically at the 2q31.1 locus. It spans approximately 60 kilobases of DNA.

Protein Information

The protein encoded by FAM60A is a protein of approximately 60 kilodaltons in size, hence the "FAM60A" nomenclature (Family with sequence similarity 60, member A). The predicted protein sequence suggests the protein is primarily intracellular. Homology searches have revealed that FAM60A contains a domain of unknown function.

Expression

FAM60A exhibits a ubiquitous expression pattern across a wide range of human tissues. Analysis of transcriptomic data indicates varying levels of expression depending on tissue type and cellular context.

Function

The precise biological function of FAM60A remains largely unknown. Research suggests potential involvement in cell cycle regulation and DNA damage response pathways, but these roles require further investigation. Limited studies have explored its role in specific cancers.

Clinical Significance

Associations between FAM60A and certain diseases, particularly cancer, have been reported in some studies. However, the evidence is currently limited, and more research is needed to determine the clinical relevance of variations or alterations in the FAM60A gene. Due to its poorly understood function, specific clinical diagnostic applications are not yet established.