David R. Brown (neuroscientist)

David R. Brown is a neuroscientist primarily known for his research on the prion protein and its role in neurodegenerative diseases, particularly transmissible spongiform encephalopathies (TSEs) such as Creutzfeldt-Jakob disease (CJD) and bovine spongiform encephalopathy (BSE), commonly known as mad cow disease.

Brown's research has focused on understanding the normal function of the prion protein (PrPC) and how its misfolding into the pathogenic form (PrPSc) leads to neuronal damage and disease progression. He has investigated the role of metal ions, particularly copper, in prion protein function and misfolding. His work has explored how the prion protein interacts with other proteins and cellular components, contributing to insights into the cellular mechanisms underlying prion diseases.

Brown has authored and co-authored numerous peer-reviewed publications in scientific journals. His research has contributed to a broader understanding of the complex mechanisms involved in prion diseases and potential therapeutic targets. His work often considers the role of oxidative stress and mitochondrial dysfunction in the pathogenesis of prion diseases.