DEPDC1B

DEPDC1B, also known as DEP domain-containing protein 1B, is a protein encoded by the DEPDC1B gene in humans. The gene is located on chromosome 16q24.1.

DEPDC1B belongs to the DEPDC1 family of proteins, characterized by the presence of a DEP (Dishevelled, Egl-10, Pleckstrin) domain. DEP domains are protein-protein interaction modules that are often involved in signal transduction pathways.

The exact function of DEPDC1B is not completely understood, but research suggests it plays a role in cell cycle regulation, specifically in cytokinesis (cell division). It has been implicated in the regulation of the Rho GTPases, which are key regulators of the actin cytoskeleton and play a critical role in cell migration, adhesion, and division. DEPDC1B is thought to act as a guanine nucleotide exchange factor (GEF) for Rho GTPases, modulating their activity.

Dysregulation of DEPDC1B expression has been linked to various cancers, suggesting a potential role in tumorigenesis. In some cancers, increased DEPDC1B expression promotes cell proliferation and metastasis, while in others, it may act as a tumor suppressor. Further research is needed to fully elucidate the role of DEPDC1B in different cancer types.

The protein has also been investigated for its possible involvement in other cellular processes beyond cancer, though concrete evidence for specific alternative functions remains limited.

Further research is necessary to fully understand the specific mechanisms of action and physiological roles of DEPDC1B.