BAIAP2

BAIAP2, also known as Brain-Specific Angiogenesis Inhibitor-Associated Protein 2, is a human gene that encodes a protein involved in signal transduction and cytoskeletal organization. It is a member of the Insulin Receptor Tyrosine Kinase Substrate p53 (IRTKS) family of proteins, characterized by a N-terminal I-BAR domain and a C-terminal SH3 domain.

The protein encoded by BAIAP2 interacts with various proteins, including BAI1 (Brain-Specific Angiogenesis Inhibitor 1), a transmembrane protein involved in tumor suppression and angiogenesis. This interaction is believed to play a role in cell migration, actin remodeling, and receptor trafficking.

BAIAP2 exists in several isoforms produced by alternative splicing. These isoforms may exhibit different tissue expression patterns and functional properties.

Research suggests that BAIAP2 is implicated in various cellular processes, including neuronal development, synapse formation, and actin dynamics. Its dysregulation has been linked to certain neurological and psychiatric disorders, as well as cancer. Further research is ongoing to fully elucidate the precise roles of BAIAP2 in these contexts.