ZDHHC14

ZDHHC14, also known as Zinc finger DHHC-type palmitoyltransferase 14, is a human gene that encodes a palmitoyltransferase enzyme. Palmitoyltransferases are a family of enzymes responsible for protein S-palmitoylation, a post-translational modification in which palmitic acid (a saturated fatty acid) is covalently attached to cysteine residues on target proteins. This modification affects protein trafficking, stability, and interactions.

The ZDHHC14 protein belongs to the ZDHHC family of palmitoyltransferases, characterized by the presence of a conserved zinc finger domain with the sequence Asp-His-His-Cys (DHHC). This DHHC motif is crucial for the enzyme's catalytic activity.

While the precise substrates and biological roles of ZDHHC14 are still being actively investigated, research suggests its involvement in various cellular processes, potentially including neurodevelopmental functions and immune regulation. Alterations in ZDHHC14 expression or function have been implicated in some neurological disorders, though further research is needed to fully elucidate its role in disease pathogenesis. The protein localizes primarily to the Golgi apparatus and endoplasmic reticulum.