UGT2B10

UGT2B10 is a gene that encodes a UDP-glucuronosyltransferase enzyme, specifically UDP-glucuronosyltransferase 2B10. This enzyme belongs to a superfamily of enzymes that catalyze the glucuronidation of various endogenous and exogenous compounds. Glucuronidation is a crucial detoxification process in the body, involving the transfer of glucuronic acid from UDP-glucuronic acid to a substrate molecule. This process increases the water solubility of the substrate, facilitating its elimination from the body via urine or bile.

The UGT2B10 enzyme is involved in the glucuronidation of various steroid hormones, including androgens. By glucuronidating androgens, UGT2B10 can influence their activity and half-life in the body. Polymorphisms within the UGT2B10 gene can lead to variations in enzyme activity, which may contribute to interindividual differences in hormone metabolism and susceptibility to hormone-related diseases.

The UGT2B10 gene is located on chromosome 4q13. Genetic variations in UGT2B10 have been studied in relation to various conditions, including prostate cancer and androgen-related disorders. Further research is ongoing to fully elucidate the role of UGT2B10 in human health and disease.