SERINC3

SERINC3 (Serine Incorporator 3) is a human gene that encodes a transmembrane protein involved in lipid metabolism and virus restriction. SERINC3 belongs to the SERINC family of proteins, which are highly conserved across eukaryotes. These proteins are believed to play a role in the incorporation of serine into lipids, influencing the composition and biophysical properties of cell membranes.

The specific function of SERINC3 is still under investigation, but it has been demonstrated to inhibit the infectivity of several viruses, including HIV-1. SERINC3 works by being incorporated into the viral envelope during viral budding, making the resulting virus less infectious. It is hypothesized that SERINC3 alters the lipid composition of the viral envelope, thereby affecting its ability to fuse with target cells and initiate infection.

SERINC3 is ubiquitously expressed in human tissues, with varying levels of expression depending on the tissue type. Its dysregulation has been implicated in various diseases, including cancer and viral infections, although its precise role in these pathologies is still being elucidated.

Further research is ongoing to fully understand the mechanisms by which SERINC3 influences lipid metabolism and restricts viral infectivity, as well as its potential as a therapeutic target for viral diseases.