PPP1R27

PPP1R27 (Protein Phosphatase 1 Regulatory Subunit 27), also known as Inhibitor of Neuronal Nitric Oxide Synthase (iNOS) binding or SPIN90, is a human gene that encodes a regulatory subunit of protein phosphatase 1 (PP1).

The encoded protein, PPP1R27, functions primarily in the brain. It is involved in regulating neuronal nitric oxide synthase (nNOS) activity by directly interacting with nNOS. This interaction inhibits nNOS, thereby controlling the production of nitric oxide (NO) in neuronal cells.

PPP1R27 contains several phosphorylation sites, suggesting its activity may be regulated by phosphorylation events. These post-translational modifications could modulate its interaction with nNOS and/or PP1, influencing its overall function in nitric oxide signaling.

Studies indicate that PPP1R27 plays a role in neuronal development, synaptic plasticity, and potentially in neurological disorders. Dysregulation of PPP1R27 expression or function has been implicated in various conditions, but further research is needed to fully understand its role in these diseases.

The gene encoding PPP1R27 is located on chromosome 17q21.31 in humans. Alternative splicing of the PPP1R27 gene can generate multiple transcript variants, which may differ in their tissue expression and/or functional properties.