PPP1R13B

PPP1R13B (Protein Phosphatase 1 Regulatory Subunit 13B) is a human gene encoding a protein that functions as a regulator of protein phosphatase 1 (PP1). It is also known as ARD (Apoptosis-Related Protein with Death domain homology) or IARD (Inhibitor of Apoptosis-Related Protein with Death domain homology).

Function:

The protein encoded by the PPP1R13B gene is involved in the regulation of apoptosis, the process of programmed cell death. Specifically, PPP1R13B interacts with and inhibits the activity of protein phosphatase 1 (PP1), a serine/threonine phosphatase that plays a crucial role in various cellular processes, including cell cycle progression, DNA replication, and apoptosis. By inhibiting PP1, PPP1R13B can influence the phosphorylation state of proteins involved in apoptosis pathways, ultimately affecting cell survival.

Structure:

The PPP1R13B protein contains a death domain homology region, which is characteristic of proteins involved in apoptosis signaling. This domain allows PPP1R13B to interact with other proteins containing death domains, facilitating its role in regulating cell death pathways.

Clinical Significance:

Alterations in the PPP1R13B gene expression or function have been implicated in various diseases, including cancer. Its role in regulating apoptosis makes it a potential target for therapeutic interventions aimed at modulating cell death in cancer cells. Research suggests that dysregulation of PPP1R13B can contribute to tumor development and progression.

Interactions:

PPP1R13B is known to interact with protein phosphatase 1 (PP1), as well as other proteins involved in apoptosis signaling pathways. These interactions are crucial for its regulatory function in cell death.

Further Research:

Ongoing research is focused on further elucidating the precise mechanisms by which PPP1R13B regulates apoptosis and its role in various disease states. Understanding these mechanisms could lead to the development of novel therapeutic strategies targeting PPP1R13B for the treatment of cancer and other diseases.