NACA (gene)

NACA, or Nascent polypeptide-associated complex alpha subunit, is a gene in humans that encodes a component of the nascent polypeptide-associated complex (NAC). NAC is a heterodimeric complex that binds to nascent polypeptide chains emerging from the ribosome.

The NACA protein, along with its partner protein NACB, plays a crucial role in protein folding, sorting, and trafficking. It acts as a chaperone, preventing premature folding or aggregation of newly synthesized proteins. NACA is also involved in targeting proteins to the endoplasmic reticulum (ER) for further processing and secretion.

The NACA gene is ubiquitously expressed in various tissues. It is considered an essential gene, meaning its disruption can have significant developmental or cellular consequences. Research suggests that NACA is involved in various cellular processes, including cell growth, differentiation, and stress response.

Further research continues to explore the specific mechanisms and pathways in which NACA participates, and its potential roles in human diseases.