Mazindol

Mazindol is a sympathomimetic amine anorectic, meaning it is a drug used to suppress appetite. It is structurally distinct from amphetamine-based anorectics.

Mechanism of Action: Mazindol primarily works by inhibiting the reuptake of norepinephrine and dopamine in the brain, leading to increased levels of these neurotransmitters in the synaptic cleft. This enhanced neurotransmission contributes to its appetite-suppressant effects.

Uses: Mazindol is approved for short-term (generally up to 12 weeks) use as an adjunct to diet and exercise in the treatment of exogenous obesity.

Side Effects: Common side effects of mazindol can include insomnia, nervousness, dry mouth, constipation, and headache. More serious side effects, although less common, may include cardiovascular effects such as increased heart rate and blood pressure.

Contraindications: Mazindol is contraindicated in individuals with certain pre-existing conditions, including advanced arteriosclerosis, severe hypertension, hyperthyroidism, and glaucoma. It is also generally avoided in individuals with a history of drug abuse or mental illness.

Drug Interactions: Mazindol can interact with other medications, including monoamine oxidase inhibitors (MAOIs), potentially leading to serious adverse effects. Caution is advised when co-administering mazindol with other sympathomimetic drugs.

Brand Names: Mazindol has been marketed under various brand names, including Sanorex and Mazanor.

Legal Status: The legal status of mazindol varies by country. It is generally a prescription medication and may be subject to regulatory controls due to its potential for abuse.