Leckfurin

Leckfurin, also known as proprotein convertase subtilisin/kexin type 6 (PCSK6), is a serine protease enzyme belonging to the proprotein convertase family. These enzymes are responsible for processing a variety of proproteins into their mature, biologically active forms.

Leckfurin is involved in several important physiological processes, including embryonic development, bone morphogenesis, and the regulation of signaling pathways. It cleaves proteins at specific motifs containing multiple basic residues, often following the consensus sequence (Arg-X-Lys/Arg-Arg).

The enzyme is synthesized as an inactive proenzyme that undergoes autocatalytic activation. It is typically found in the Golgi apparatus, where it interacts with other processing enzymes and substrates.

Mutations in the gene encoding Leckfurin have been linked to various developmental disorders, particularly those affecting skeletal formation. Research also suggests a role for Leckfurin in cancer progression and metastasis, although its precise function in these contexts is still being investigated.

Further research is needed to fully elucidate the scope of Leckfurin's functions and its potential as a therapeutic target.